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RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential

Seungyoon Nam1,2,3,4, Jung Ho Kim5,6, Dae Ho Lee7,8

  • 1Department of Genome Medicine and Science, College of Medicine, Gachon University, Incheon, South Korea.

Frontiers in Genetics
|June 4, 2019
PubMed

Insights

The small GTPase RHOA is linked to gastric cancer (GC) progression, particularly invasion and metastasis. Targeting RHOA may offer new therapeutic strategies for this lethal malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomedical Science

Background:

  • RHOA (Ras homolog family member A) is a key signal mediator and small GTPase.
  • Emerging evidence links RHOA to the progression of various cancers.

Purpose of the Study:

  • To review the existing literature on RHOA's role in gastric cancer (GC) signaling.
  • To assess the clinical significance and therapeutic potential of RHOA in GC.

Main Methods:

  • Literature appraisal of RHOA's involvement in GC.
  • Analysis of RHOA activity in relation to cancer hallmarks.
  • Review of RHOA's influence on chemotherapy and targeted therapies.

Main Results:

  • RHOA is strongly associated with the "activation of invasion and metastasis" hallmark in GC.
  • RHOA expression correlates with the Lauren classification diffuse subtype and poorly differentiated GC.
  • RHOA signaling impacts the efficacy of common chemotherapeutics and may be antagonized by dietary compounds.

Conclusions:

  • RHOA plays a significant role in GC progression, invasion, and metastasis.
  • RHOA represents a potential therapeutic target for GC, with implications for chemotherapy response.
  • There is a critical need for further research into RHOA-targeted therapies for gastric cancer due to limited current options.
Keywords:
RHOAfunctionsgastric cancerstomach cancertherapeutics

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