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Does an interaction exist between ketamine hydrochloride and Becton Dickinson syringes?
M Closset1, J D Hecq2,3, E Gonzalez1,3
1Medical Laboratory, CHU Dinant Godinne | UCL Namur, Yvoir, Belgium.
Summary
Ketamine hydrochloride (HCl) stored in Becton Dickinson (BD) 3 mL syringes showed no degradation or physical changes over 50 days. This indicates ketamine HCl is stable for extended storage in these specific syringes.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Becton Dickinson (BD) issued an alert regarding potential interactions between drug molecules and syringes.
- The institution's Centralized IntraVenous Additives Service used BD 3 mL syringes for ketamine HCl storage.
Purpose of the Study:
- To evaluate the interaction and stability of ketamine hydrochloride (HCl) when stored in BD 3 mL syringes.
Main Methods:
- Tested stored ketamine HCl solutions in BD syringes over 50 days at room temperature.
- Monitored pH, visual appearance, microscopic inspection, and concentration via ultra-high-performance liquid chromatography-diode array detector.
Main Results:
- No physical changes or pH modifications were observed in the ketamine HCl solutions.
- Spectrophotometric and chromatographic analyses confirmed the stability of ketamine HCl concentrations.
Conclusions:
- Ketamine HCl can be safely stored in BD 3 mL syringes for at least 50 days under the study's conditions.
- No significant sorption or degradation occurred, confirming syringe compatibility.
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