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Updated: Jan 24, 2026
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Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization
Published on: September 29, 2015
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Physicochemical stability of voriconazole in elastomeric devices
Harmanjeet Harmanjeet1, Syed Tabish R Zaidi1, Long Chiau Ming1
1Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Summary
Voriconazole is stable in elastomeric pumps for prolonged intravenous treatment of invasive aspergillosis, enabling early hospital discharge for immunocompromised patients when oral administration is not feasible.
Area of Science:
- Pharmaceutical Sciences
- Clinical Pharmacy
- Mycology
Background:
- Invasive aspergillosis (IA) presents a significant mortality risk in immunocompromised individuals.
- Prolonged intravenous voriconazole is often necessary due to oral mucositis and unreliable oral bioavailability.
- Elastomeric pumps offer a potential solution for extended home-based intravenous therapy.
Purpose of the Study:
- To assess the physicochemical stability of voriconazole in elastomeric pumps.
- To determine voriconazole stability at various temperatures and time points relevant to clinical use.
Main Methods:
- Voriconazole (2 mg/mL) was prepared in 0.9% sodium chloride and 5% glucose solutions within elastomeric pumps.
- Pumps were stored at 4°C for 96 hours, and at 25°C and 35°C for 4 hours.
- Stability was evaluated using high-performance liquid chromatography, visual inspection, pH, and microscopic analysis.
Main Results:
- Voriconazole demonstrated stability for at least 96 hours at 4°C and 4 hours at 25°C and 35°C.
- No significant changes in particle formation, color, or pH were observed during the study.
- The drug remained stable in both 0.9% sodium chloride and 5% glucose admixtures.
Conclusions:
- Elastomeric pump administration of voriconazole is chemically and physically stable under tested conditions.
- This method supports early hospital discharge for patients requiring extended intravenous voriconazole therapy.
- Facilitates outpatient management when oral voriconazole is contraindicated or ineffective.
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