Related Experiment Video
Updated: Jan 24, 2026

10:52
Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh
Published on: September 11, 2021
5.8K
Diaphragmatic Hernia Repair Using Biosynthetic Tissue Reinforcement Patch: A Case Series Experience
David Rubay1, Levonti Ohanisian2, StevenClaude D White3
1Surgery, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Cureus
|June 4, 2019
Summary
Diaphragmatic hernia repair using GORE® BIO-A® Tissue Reinforcement shows promise. This extracellular matrix scaffold aids tissue repair, potentially reducing complications and recurrence in surgical patients.
Area of Science:
- Surgical innovation
- Biomaterials science
- Regenerative medicine
Background:
- Diaphragmatic hernias present a common surgical challenge.
- Current repair methods are associated with significant complication and recurrence rates.
- Extracellular matrix scaffolds offer a potential solution for tissue repair via constructive remodeling.
Observation:
- This study details the application of the GORE® BIO-A® Tissue Reinforcement patch.
- The patch is an extracellular matrix scaffold designed for tissue repair.
- The focus is on its use in diaphragmatic hernia repair.
Findings:
- The GORE® BIO-A® Tissue Reinforcement patch was utilized in a series of diaphragmatic hernia repair cases.
- The use of this scaffold as a surgical adjunct was described.
- The study presents the outcomes of these patient cases.
Implications:
- This approach may offer an improved method for diaphragmatic hernia repair.
- Utilizing extracellular matrix scaffolds could lead to better surgical outcomes.
- Further research into biomaterial-assisted tissue regeneration in hernia repair is warranted.
Related Concept Videos
Long-patch Base Excision Repair
7.9K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
7.9K
Reinforcement
872
Positive and negative reinforcement are key concepts in operant conditioning, a learning process where the consequences of a behavior affect the likelihood of that behavior being repeated.
Positive reinforcement occurs when a behavior is followed by the presentation of a rewarding stimulus, increasing the frequency of that behavior. For example:
Positive reinforcement occurs when a behavior is followed by the presentation of a rewarding stimulus, increasing the frequency of that behavior. For example:
872
Mismatch Repair
43.5K
Overview
43.5K
Amino Acid Biosynthetic Pathways
1.1K
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
1.1K
Overview of DNA Repair
33.5K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Chemically...
33.5K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
7.5K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.5K

