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Acute Myocardial Infarction in Rats
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Unmet Needs in Managing Myocardial Infarction in Patients With Malignancy

Taku Inohara1,2, Ayaka Endo2,3, Chiara Melloni1

  • 1Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, United States.

Frontiers in Cardiovascular Medicine
|June 4, 2019
PubMed

Insights

Cancer patients have a threefold higher risk of myocardial infarction (MI). Managing MI in cancer patients is challenging due to complex pathophysiology, but guideline-recommended therapies show similar benefits.

Area of Science:

  • Cardiology
  • Oncology

Background:

  • Patients with cancer have a significantly elevated risk of arterial thromboembolism, particularly myocardial infarction (MI).
  • The risk is influenced by cardiovascular factors, cancer characteristics, and treatments, complicating management.
  • Balancing thrombotic and bleeding risks is a major clinical challenge in this population.

Purpose of the Study:

  • To review the evidence, challenges, and future directions for managing MI in cancer patients.
  • To focus on the role of invasive strategies in the simultaneous treatment of MI and cancer.

Main Methods:

  • This is a review article summarizing existing literature.
  • The review synthesizes evidence on MI management in cancer patients, considering risk factors and treatment outcomes.

Main Results:

  • Patients with cancer face a 3-fold increased risk of MI compared to those without cancer.
  • Guideline-recommended therapies for MI, including antiplatelet agents and revascularization, show comparable clinical benefits in cancer patients despite limited evidence.
  • A limited proportion of cancer patients presenting with MI receive guideline-recommended treatment.

Conclusions:

  • Simultaneous management of MI and cancer presents unique challenges due to cancer's pathophysiology.
  • Invasive strategies may play a role in managing MI in cancer patients, requiring careful consideration of risks and benefits.
  • Further research is needed to optimize treatment protocols for MI in the context of cancer.

Keywords:
arterial thrombosiscancerchemotherapyinvasive strategymyocardial infarction

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