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The impact of monocyte to high-density lipoprotein ratio on reduced renal function: insights from a large population

Wen-Rui Shi1, Hao-Yu Wang1, Shuang Chen1

  • 1Department of Cardiology, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, PR China.

Biomarkers in Medicine
|June 4, 2019
PubMed

Insights

The monocyte to HDL cholesterol ratio (MHR) is linked to reduced kidney function. This ratio can help doctors better predict the risk of developing kidney disease.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomarkers

Background:

  • Reduced renal function is a growing public health concern.
  • Atherosclerosis is a key factor in cardiovascular and renal diseases.
  • Novel biomarkers are needed for improved risk stratification of renal function decline.

Purpose of the Study:

  • To evaluate the monocyte to HDL cholesterol ratio (MHR) as a predictor of reduced renal function.
  • To determine if MHR improves risk stratification for renal function reduction.
  • To investigate the association between MHR and atherosclerosis in relation to kidney function.

Main Methods:

  • Cross-sectional study of 8159 subjects from Northeast China (2013).
  • Analysis of demographic data, MHR levels, and renal function.
  • Statistical methods including correlation analysis and net reclassification improvement (NRI).

Main Results:

  • Each standard deviation increase in MHR was associated with a 42.9% increased risk of reduced renal function in males.
  • In females, MHR showed a strong correlation with reduced renal function up to a breakpoint (MHR = 0.25).
  • NRI analysis confirmed MHR's value in improving risk classification for renal function reduction (0.199; p=0.021).

Conclusions:

  • The monocyte to HDL cholesterol ratio (MHR) is independently associated with reduced renal function.
  • MHR demonstrates potential to refine the risk stratification of renal function reduction.
  • MHR may serve as a valuable biomarker in assessing atherosclerosis-related renal risk.

Keywords:
atherosclerosisinflammationlipid accumulationmonocyte to high-density lipoprotein cholesterol ratioreduced renal function

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