Altered signature of apoptotic endothelial cell-derived microvesicles predicts chronic heart failure phenotypes

Aim: to evaluate the associations between signatures of apoptotic endothelial cell-derived microvesicles (MVs) with phenotypes of chronic heart failure (HF). Methods: The study cohort consisted of 388 prospectively involved subjects with HF patients with predominantly reduced left ventricular ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF). All biomarkers were measured at baseline. Results: The number of circulating CD31⁺/annexin V⁺ MVs in HFrEF and HFmrEF patients was similar. The number of circulating CD144⁺/annexin V⁺ MVs in HFrEF patients was significantly higher than HFmrEF and HFpEF. We determined that a combination of number of circulating CD31⁺/annexin V⁺ MVs and Gal-3 was the best predictor of HFpEF and that number of circulating CD144⁺/annexin V⁺ MVs is able to increase predictive capabilities of soluble ST2 (sST2) and Gal-3 for HFrEF. Conclusion: We found that the number of circulating CD31⁺/annexin V⁺ MVs may improve a predictive capacity for conventional HF biomarkers.