Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study
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View abstract on PubMed
Summary
This summary is machine-generated.Alzheimer
Area Of Science
- Neurology
- Neuroimaging
- Gerontology
Background
- Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) plaques and tau tangles.
- In vivo PET imaging allows visualization of Aβ and tau.
- Understanding their progression in normal aging is key for AD prevention trials.
Purpose Of The Study
- To examine the 7-year associations between Aβ, tau, and cognitive changes in clinically normal older adults.
- To investigate the sequential relationship between Aβ accumulation, tau deposition, and cognitive decline.
Main Methods
- Prospective cohort study (2010-2017) at Harvard Aging Brain Study.
- Included 60 clinically normal participants with serial Aβ and tau PET scans.
- Cognition assessed annually; progression to mild cognitive impairment evaluated.
Main Results
- Increased Aβ was linked to subsequent tau accumulation.
- Tau accumulation correlated with cognitive decline, independent of baseline Aβ and tau.
- Participants progressing to mild cognitive impairment showed greater tau changes.
Conclusions
- A sequential pathological cascade from Aβ to tau to cognitive impairment occurs in normal aging.
- Serial tau-PET imaging is crucial for tracking AD progression.
- Serial amyloid-PET imaging can detect early AD pathological changes.
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