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Updated: Jan 24, 2026

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays

Published on: August 13, 2017

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Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

Andrew R Clark1, Michael Ohlmeyer2

  • 1Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.

Pharmacology & Therapeutics
|June 4, 2019
PubMed

Insights

Protein phosphatase 2A (PP2A) acts as a tumor suppressor by regulating cell signaling. New research suggests PP2A also controls inflammation, indicating PP2A-activating drugs could treat both cancer and inflammatory diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Protein phosphatase 2A (PP2A) is a crucial enzyme for dephosphorylation.
  • PP2A is recognized for its tumor suppressor role by inhibiting oncogenic signaling pathways.
  • Its role in inflammation is less understood but increasingly recognized.

Purpose of the Study:

  • To explore the role of PP2A in regulating inflammatory responses.
  • To investigate the potential of PP2A-activating drugs (PADs) in treating inflammation-mediated diseases.

Main Methods:

  • Literature review and conceptual analysis of PP2A's signaling roles.
  • Examination of PP2A's inhibitory effects on key inflammatory pathways.

Main Results:

  • PP2A dephosphorylates key proteins involved in cellular transformation and metastasis.
  • PP2A also targets signaling pathways critical for inflammatory responses.
  • Evidence suggests PP2A acts as a negative regulator of inflammation.

Conclusions:

  • PP2A's dual role in suppressing cancer and inflammation is highlighted.
  • PADs represent a promising therapeutic strategy for both cancer and inflammatory conditions.
  • Further research into PP2A modulators for inflammatory diseases is warranted.
Keywords:
Alzheimer’s diseaseCancerInflammationMultiple sclerosisNeurodegenerationProtein phosphatase 2A

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