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Updated: Jan 24, 2026

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
Published on: August 26, 2014
Infantile Optic Pathway Glioblastoma
Declan G Siedler1, Jessica C Beechey2, Peter J Jessup2
1Department of Neurosurgery, Royal Hobart Hospital, Hobart, Tasmania, Australia.
Insights
A rare infant optic pathway glioblastoma was diagnosed in a 6-month-old. The patient remained stable at 1 year, highlighting the need for specialized care for this rare pediatric brain tumor.
Area of Science:
- Pediatric neuro-oncology
- Neuro-ophthalmology
Background:
- Optic pathway gliomas and glioblastomas are rare in infants.
- Early diagnosis and intervention are critical for managing pediatric brain tumors.
Background:
Optic pathway gliomas and glioblastomas remain a rare entity within the infant population.
Case Description:
We outline the case of a 6-month-old female who presented with failure to thrive, nystagmus and features of raised intracranial pressure. Subsequent magnetic resonance imaging demonstrated an infiltrating tumor radiating from the optic nerves bilaterally. She underwent emergent ventriculoperitoneal shunting and biopsy. Histology confirmed a World Health Organization grade IV glioblastoma.
Conclusions:
The patient remained clinically and radiologically stable at 1 year. Optic pathway glioblastoma in this population is a previously undescribed entity that requires multidisciplinary input to guide ongoing therapy.
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