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In vivo 19F MRI for Cell Tracking
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Technical note: MLC-tracking performance on the Elekta unity MRI-linac.

M Glitzner1,2, P L Woodhead1,3, P T S Borman1

  • 1Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Physics in Medicine and Biology
|June 4, 2019
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Summary
This summary is machine-generated.

This study demonstrates the feasibility of combining magnetic resonance imaging (MRI)-guided radiotherapy with multileaf collimator (MLC)-tracking on clinical hardware. Accelerating MRI acquisition is key for improving real-time adaptive radiotherapy.

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Area of Science:

  • Medical physics
  • Radiation oncology
  • Medical imaging

Background:

  • Multileaf collimator (MLC)-tracking and magnetic resonance imaging (MRI)-guided radiotherapy are advanced techniques for treating mobile tumors.
  • Combining these technologies on clinically available hardware has not been previously investigated.

Purpose of the Study:

  • To assess the technical feasibility of integrating MLC-tracking with an MRI-guided linear accelerator (linac).
  • To quantify the latencies and geometric errors associated with MLC-tracking, both in isolation and when guided by real-time MRI.

Main Methods:

  • Characterized the MLC-tracking system's performance using an ideal position sensor to isolate MLC-only errors.
  • Repeated the analysis using real-time MRI as the positioning source for the MLC on a clinical MRI-linac.
  • Quantified system latencies and geometric errors under both conditions.

Main Results:

  • Isolated MLC-tracking exhibited low latencies (20.67 ms) and minimal overshooting.
  • MRI-guided tracking showed significantly higher latencies (347.45 ms at 4 Hz, 204 ms at 8 Hz).
  • MLC-related errors were found to be negligible compared to MRI-induced errors.

Conclusions:

  • MLC-tracking is technically feasible on an Elekta Unity MRI-linac.
  • The primary source of latency and geometric error in this combined system originates from the MRI acquisition process.
  • Optimizing MRI acquisition speed is crucial for enhancing real-time MRI-guided adaptive radiotherapy.