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Resveratrol Action on Lipid Metabolism in Cancer
Terézia Kisková1, Monika Kassayová2
1Department of Animal Physiology, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovak Republic. terezia.kiskova@gmail.com.
Abstract:
Cancer diseases have the leading position in human mortality nowadays. The age of oncologic patients is still decreasing, and the entire scientific society is eager for new ways to fight against cancer. One of the most discussed issues is prevention by means of natural substances. Resveratrol is a naturally occurring plant polyphenol with proven antioxidant, anti-inflammatory, and anticancer effects. Tumor cells display specific changes in the metabolism of various lipids. Resveratrol alters lipid metabolism in cancer, thereby affecting storage of energy, cell signaling, proliferation, progression, and invasiveness of cancer cells. At the whole organism level, it contributes to the optimal metabolism extent with respect to the demands of the organism. Thus, resveratrol could be used as a preventive and anticancer agent. In this review, we focus on some of the plethora of lipid pathways and signal molecules which are affected by resveratrol during carcinogenesis.
Insights
Resveratrol, a natural polyphenol, shows promise in cancer prevention and treatment by altering cancer cell lipid metabolism. This impacts energy storage, cell signaling, and cancer progression, offering a potential natural therapeutic agent.
Area of Science:
- Oncology
- Biochemistry
- Natural Product Chemistry
Background:
- Cancer remains a leading cause of mortality globally, with a decreasing patient age.
- There is a growing need for novel cancer prevention and treatment strategies.
- Natural compounds, like resveratrol, are being investigated for their therapeutic potential.
Purpose of the Study:
- To review the effects of resveratrol on lipid metabolism in cancer.
- To explore how resveratrol influences cancer cell signaling, proliferation, and invasiveness.
- To assess resveratrol's potential as a preventive and anticancer agent.
Main Methods:
- Literature review focusing on resveratrol's impact on lipid pathways in cancer.
- Analysis of studies investigating resveratrol's effects on cellular metabolism and signaling.
- Examination of resveratrol's role in carcinogenesis at the organism level.
Main Results:
- Resveratrol demonstrably alters lipid metabolism in tumor cells.
- These alterations affect critical cancer processes including energy storage, cell signaling, proliferation, and invasiveness.
- Resveratrol contributes to maintaining optimal organism metabolism.
Conclusions:
- Resveratrol exhibits significant anticancer properties by modulating lipid metabolism.
- Its multifaceted effects suggest potential for use in cancer prevention and therapy.
- Further research into resveratrol's mechanisms in carcinogenesis is warranted.
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