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Ameliorative effect of synthesized silver nanoparticles by green route method from Zingiber zerumbet on mycoplasmal

Yong Yang1,2, Wenping Song3, Zongbo Chen4

  • 1a Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.

Artificial Cells, Nanomedicine, and Biotechnology
|June 5, 2019
PubMed

Insights

This study explored Zingiber zerumbet-based silver nanoparticles for treating Mycoplasma pneumoniae infections. The findings suggest potential therapeutic applications for these nanoparticles against pneumonia.

Area of Science:

  • Pharmacology
  • Nanotechnology
  • Microbiology

Background:

  • Mycoplasma pneumoniae (MP) causes respiratory infections, including community-acquired pneumonia, particularly in children and adolescents.
  • Zingiber zerumbet (L.) is a traditional medicinal plant rich in bioactive compounds like polyphenols, alkaloids, and terpenes, known for anti-inflammatory and immune-modulating properties.
  • No prior research has investigated the antipneumonial activity of Zingiber zerumbet-based silver nanoparticles.

Purpose of the Study:

  • To biosynthesize silver nanoparticles using Zingiber zerumbet extract.
  • To evaluate the anti-pneumonial potential of these nanoparticles against Mycoplasma pneumoniae-induced pneumonia in a rat model.

Main Methods:

  • Biosynthesis of silver nanoparticles using Zingiber zerumbet extract.
  • Induction of Mycoplasma pneumoniae pneumonia in experimental rats.
  • Assessment of the therapeutic efficacy of Zingiber zerumbet-based silver nanoparticles.

Main Results:

  • The study successfully synthesized Zingiber zerumbet-based silver nanoparticles.
  • The nanoparticles demonstrated significant anti-pneumonial activity in the experimental rat model.
  • Further analysis revealed the therapeutic potential of these nanoparticles in combating Mycoplasma pneumoniae infections.

Conclusions:

  • Zingiber zerumbet-based silver nanoparticles show promising anti-pneumonial effects.
  • This study provides a foundation for developing novel nanoparticle-based therapies for respiratory infections.
  • Further research is warranted to elucidate the precise mechanisms of action and clinical applicability.
Keywords:
FT-IRPneumoniaTEMantimicrobial activitymycoplasmasilver nanoparticle

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