Immunization and multiple sclerosis: Recommendations from the French multiple sclerosis society

Area of Science:

• Neurology
• Immunology
• Public Health

Background:

• Historical concerns linked vaccines to multiple sclerosis (MS) onset and relapses.
• Current concerns involve infection risks and reduced vaccine efficacy in patients on disease-modifying therapies (DMTs).

Purpose of the Study:

• To establish evidence-based recommendations for immunizing patients with multiple sclerosis.
• To address concerns regarding vaccine safety and effectiveness in the context of MS and its treatments.

Main Methods:

• Systematic literature search (1975-2018) using Medline and university databases.
• RAND/UCLA appropriateness method for expert consensus on immunization in MS.
• Evaluation and rating by 28 MS experts and 110 healthcare professionals.

Main Results:

• Vaccination status should be checked at MS diagnosis, before initiating DMTs.
• Standard French vaccination schedules, including seasonal influenza, are recommended for MS patients.
• Live attenuated vaccines are contraindicated during immunosuppressive therapy; other vaccines' efficacy may be reduced.

Conclusions:

• Physicians and patients need to be informed about current MS immunization recommendations.
• Proactive vaccination strategies are crucial for managing MS patients' health.
• Updated guidance ensures optimal vaccine use while minimizing risks in MS care.