Related Experiment Video
Updated: Jan 24, 2026
08:34
A Quick and Efficient Method for the Purification of Endoderm Cells Generated from Human Embryonic Stem Cells
Published on: March 3, 2016
8.8K
The endoderm: a divergent cell lineage with many commonalities
Sonja Nowotschin1, Anna-Katerina Hadjantonakis2, Kyra Campbell3,4
1Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Development (Cambridge, England)
|June 5, 2019
Summary
Endoderm development involves shared cell behaviors like EMTs and METs across species. Cross-organismal studies reveal conserved mechanisms in internal organ formation, advancing developmental biology understanding.
Area of Science:
- Developmental Biology
- Cell Biology
- Comparative Biology
Background:
- The endoderm is a crucial progenitor tissue for internal organs in humans.
- Genetic studies have identified divergent upstream signals specifying endoderm identity across species.
Purpose of the Study:
- To review and highlight shared cell behaviors in endodermal morphogenesis.
- To emphasize the value of cross-organismal studies for understanding endoderm development.
Main Methods:
- Literature review of genetic and cell behavior studies in endoderm development.
- Comparative analysis of endodermal morphogenesis across different model systems.
Main Results:
- Identified conserved cell behaviors including epithelial-to-mesenchymal transitions (EMTs) and mesenchymal-to-epithelial transitions (METs).
- Revealed shared features in collective cell migration during endoderm development.
Conclusions:
- Cross-organismal comparisons offer valuable insights into conserved endodermal morphogenesis.
- Understanding shared cell behaviors advances knowledge of internal organ formation.
Related Concept Videos
01:15Divergence and Curl
3.1K
The divergence of a vector field at a point is the net outward flow of the flux out of a small volume through a closed surface enclosing the volume, as the volume tends to zero. More practically, divergence measures how much a vector field spreads out or diverges from a given point. For an outgoing flux, conventionally, the divergence is positive. The diverging point is often called the "source" of the field. Meanwhile, the negative divergence of a vector field at a point means that the vector...
3.1K
01:06Divergence and Stokes' Theorems
3.6K
The divergence and Stokes' theorems are a variation of Green's theorem in a higher dimension. They are also a generalization of the fundamental theorem of calculus. The divergence theorem and Stokes' theorem are in a way similar to each other; The divergence theorem relates to the dot product of a vector, while Stokes' theorem relates to the curl of a vector. Many applications in physics and engineering make use of the divergence and Stokes' theorems, enabling us to write...
3.6K
02:37Gene Duplication and Divergence
7.9K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
7.9K
03:24Common Ion Effect
46.1K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
46.1K
01:25Divergence and Curl of Electric Field
7.2K
The divergence of a vector is a measure of how much the vector spreads out (diverges) from a point. For example, an electric field vector diverges from the positive charge and converges at the negative charge. The divergence of an electric field is derived using Gauss's law and is equal to the charge density divided by the permittivity of space. Mathematically, it is expressed as
7.2K
01:26Divergence and Curl of Magnetic Field
3.9K
The magnetic field due to a volume current distribution given by the Biot–Savart Law can be expressed as follows:
3.9K