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Updated: Jan 23, 2026

Construction of Homozygous Mutants of Migratory Locust Using CRISPR/Cas9 Technology
Published on: March 16, 2022
CCR5-∆32 is deleterious in the homozygous state in humans
Xinzhu Wei1, Rasmus Nielsen2,3
1Department of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA, USA. aprilwei@berkeley.edu.
Abstract:
We use the genotyping and death register information of 409,693 individuals of British ancestry to investigate fitness effects of the CCR5-∆32 mutation. We estimate a 21% increase in the all-cause mortality rate in individuals who are homozygous for the ∆32 allele. A deleterious effect of the ∆32/∆32 mutation is also independently supported by a significant deviation from the Hardy-Weinberg equilibrium (HWE) due to a deficiency of ∆32/∆32 individuals at the time of recruitment.
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