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Leprosy, liver and jaundice.

B Kumar1, A Koshy, S Kaur

  • 1Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Leprosy
|April 1, 1987
PubMed
Summary

Leprosy patients experiencing jaundice showed significant liver enzyme and bilirubin abnormalities. These issues persisted long-term, suggesting non-A, non-B viral hepatitis as a potential cause unrelated to leprosy medications.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Dermatology

Background:

  • Leprosy, a chronic infectious disease, can present with various complications.
  • Jaundice is an uncommon but significant manifestation in leprosy patients.
  • Understanding the etiology of jaundice in leprosy is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical and biochemical profile of leprosy patients who developed jaundice.
  • To identify potential causes of jaundice in this patient cohort.
  • To compare the course of prolonged jaundice in leprosy with other conditions.

Main Methods:

  • Investigated nine leprosy patients (5 BL, 4 LL) with jaundice.
  • Assessed clinical signs (hepatomegaly, splenomegaly).
  • Monitored liver enzymes and serum bilirubin levels; tested for Hepatitis B surface antigen (HBsAg) and anti-HAV IgM.

Main Results:

  • All patients exhibited significant alterations in liver enzymes and serum bilirubin.
  • Abnormalities persisted longer than expected, even after clinical recovery.
  • Hepatitis B and A viruses were ruled out in most cases, with one HBsAg-positive patient.
  • Antileprosy drugs were not implicated, as recovery continued after restarting treatment.

Conclusions:

  • Leprosy patients can develop prolonged jaundice with significant liver enzyme disturbances.
  • Non-A, non-B viral hepatitis is a potential cause of jaundice in leprosy.
  • Further investigation into viral etiologies is warranted for unexplained hepatitis in leprosy.

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