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Platelet Indices as a Predictor of Microvascular Complications in Type 2 Diabetes

Rajas S Walinjkar1, Satish Khadse1, Sunil Kumar1

  • 1Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe University of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Indian Journal of Endocrinology and Metabolism
|June 5, 2019
PubMed

Insights

Platelet indices like MPV and PDW are elevated in type 2 diabetes patients and correlate with microvascular complications. These markers may indicate increased risk for diabetic complications.

Area of Science:

  • Endocrinology
  • Hematology
  • Vascular Biology

Background:

  • Type 2 diabetes mellitus (T2DM) is linked to micro- and macrovascular complications, reducing quality of life.
  • Platelet indices, routinely measured, may indicate endothelial dysfunction and microvascular issues in T2DM.

Purpose of the Study:

  • To investigate the correlation between platelet indices and microvascular complications in patients with T2DM.

Main Methods:

  • A study involving 125 T2DM patients and age/sex-matched controls.
  • Evaluation of microvascular complications, platelet indices (MPV, PCT, PDW, P/LCR), HbA1C, and Sr. Creatinine.
  • Statistical analysis using SPSS 17.0.

Main Results:

  • Platelet indices (MPV, PCT, PDW, P/LCR) were significantly higher in T2DM patients compared to controls.
  • Elevated MPV, PDW, and P/LCR were more pronounced in T2DM patients with microvascular complications.
  • Platelet dysfunction correlated positively with HbA1C, retinopathy, nephropathy, and neuropathy.

Conclusions:

  • Changes in platelet indices are statistically associated with T2DM.
  • Platelet indices may serve as potential biomarkers for microvascular complications in T2DM.
Abstract

Keywords:
Diabetic nephropathydiabetic neuropathydiabetic retinopathymicrovascular complicationsplatelet indicestype 2 diabetes mellitus

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