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Updated: Jan 23, 2026
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
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Risk of Malignancy in FDG-Avid Thyroid Incidentalomas on PET/CT: A Prospective Study
Chadi Nimeh Abdel-Halim1, Tine Rosenberg2, Kristine Bjørndal2
1Department of ORL - Head and Neck Surgery and Audiology, Odense University Hospital, J. B. Winsløws Vej 4, 5000, Odense, Denmark. chadi.nimeh.abdel-halim3@rsyd.dk.
World Journal of Surgery
|June 5, 2019
Summary
The study found a 24% malignancy risk in focal FDG-avid thyroid incidentalomas (FFTIs) managed in a Head and Neck Cancer (HNC) fast track program. This highlights the importance of prompt evaluation for these incidental findings.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Focal FDG-avid thyroid incidentalomas (FFTIs) present a substantial risk of malignancy.
- Patients with FFTIs are often referred to Head and Neck Cancer (HNC) fast track programs for evaluation.
Purpose of the Study:
- To determine the malignancy risk of FFTIs managed within an HNC fast track program.
Main Methods:
- Prospective cohort study of patients with FFTIs referred to Odense University Hospital's HNC fast track program (September 2016 - August 2017).
- All patients underwent ultrasonography (US); most also had fine-needle aspiration biopsy (FNAB).
- Surgical removal was planned for nodules with Bethesda cytology 1, 3, 4, 5, or 6.
Main Results:
- 104 patients were included; 101 underwent FNAB.
- The overall risk of malignancy for FFTIs was 24% (23/95) based on unequivocal cytology and/or histology.
- Irregular margins on US were the only significant predictor of malignancy (sensitivity 47%, specificity 96%).
Conclusions:
- The malignancy risk for FFTIs managed in this HNC fast track program is 24%.
- This finding underscores the necessity of efficient diagnostic pathways for thyroid incidentalomas detected on PET/CT.
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