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Updated: Jan 23, 2026
11:27
Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
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How Do Contrast Agents Affect Cardiac Markers and Coagulation Tests? Experimental Study.
Mustafa Begenc Tascanov1, Ataman Gönel2
1Department of Cardiology, Harran University, Sanliurfa, Turkey.
Combinatorial Chemistry & High Throughput Screening
|June 5, 2019
Summary
Contrast agents can interfere with cardiac marker tests, leading to false negatives in troponin and NT-proBNP. Clinicians should carefully interpret cardiac test results after contrast imaging, especially within the first hour.
Area of Science:
- Clinical Chemistry
- Diagnostic Medicine
- Medical Laboratory Science
Background:
- Biotin interference with troponin and NT-proBNP assays prompted method updates.
- Incompatible cardiac test results can impact patient morbidity and mortality risks.
Purpose of the Study:
- To evaluate interference from 7 contrast agents on cardiac markers (Troponin-I, NT-proBNP, CK-MB, CK, AST, LDH) and coagulation tests (PT, APTT).
Main Methods:
- Contrast media were added to control materials following an interference protocol.
- Cardiac markers and coagulation parameters were measured using multiple automated analyzers.
- Deviations from target values were quantified to assess interference levels.
Main Results:
- Contrast media caused significant negative interference in troponin levels (57.43%-62.87%).
- False negativity in NT-proBNP tests ranged widely (6.11%-96.01%) depending on the contrast agent.
- Enzymes and coagulation tests showed less susceptibility to contrast agent interference.
Conclusions:
- Contrast media can induce false negatives in cardiac troponin-I (cTnI) and NT-proBNP assays.
- Selecting contrast agents with minimal interference is recommended.
- Exercise caution when interpreting cardiac marker results obtained within one hour post-contrast imaging.
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