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Updated: Jan 23, 2026
09:03
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
10.1K
Cell Therapy in Solid Organ Transplantation
Songjie Cai1, Anil Chandraker1
1Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, United States.
Current Gene Therapy
|June 5, 2019
Summary
Cell therapy offers a promising alternative to traditional immunosuppressive drugs for organ transplantation, potentially reducing risks and improving long-term graft survival by utilizing regulatory cells.
Area of Science:
- Immunology and Transplantation Science
Background:
- Organ transplantation is the definitive cure for end-stage organ failure.
- Current immunosuppressive drugs face limitations including non-specific immune suppression, increasing risks of infection and cancer, and chronic toxicity.
- Cell therapy presents an innovative approach to mitigate immunosuppression in transplantation.
Purpose of the Study:
- To review the mechanisms of transplant rejection.
- To discuss the limitations of current immunosuppressive drugs.
- To explore the therapeutic potential of regulatory cells in transplantation.
Main Methods:
- Review of preclinical studies on suppressor cells (regulatory T cells, regulatory B cells, tolerogenic dendritic cells).
- Analysis of recent clinical trials involving cell-based therapies in solid organ transplantation.
- Discussion of the rejection process and current immunosuppressive strategies.
Main Results:
- Preclinical data demonstrate the efficacy and safety of various suppressor cells.
- Emerging clinical trials indicate promise for cell-based therapies in enhancing transplant outcomes.
- Regulatory cells show potential for minimizing immunosuppression and improving graft survival.
Conclusions:
- Cell therapy is a promising strategy to overcome the limitations of conventional immunosuppression in organ transplantation.
- The use of regulatory cells holds significant potential for improving long-term graft survival and patient safety.
- Further research and clinical application of cell-based therapies are warranted to optimize transplantation outcomes.
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