Styrylquinoline - A Versatile Scaffold in Medicinal Chemistry.

Area of Science:

• Medicinal Chemistry
• Organic Chemistry
• Drug Design

Background:

• Styrylquinolines are lipophilic, aromatic compounds with a century-long history.
• Early development was hindered by low selectivity, toxicity, and unclear mechanisms of action.
• These compounds were largely neglected for extended periods.

Purpose of the Study:

• To review and analyze the activity spectrum of styrylquinolines.
• To explore their applications in modern drug design.
• To highlight their recent resurgence in scientific interest.

Main Methods:

• Comprehensive literature review of styrylquinoline research.
• Analysis of reported biological activities and synthetic strategies.
• Evaluation of their potential in medicinal and material chemistry.

Main Results:

• Styrylquinoline derivatives show significant antiretroviral activity, particularly as HIV integrase inhibitors.
• Revisited research confirms their antifungal and anticancer properties.
• Recent findings have re-established styrylquinolines in medicinal and material chemistry.

Conclusions:

• Styrylquinolines have regained prominence in medicinal chemistry.
• New activities and clarified mechanisms of action support their therapeutic potential.
• Several styrylquinoline drug candidates are progressing through clinical trials.