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Related Concept Videos

Binge Eating Disorders01:23

Binge Eating Disorders

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Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
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Normal stress is a type of stress that occurs when forces act perpendicular, or normal, to a material's cross-sectional area. This stress often arises in structures when subjected to axial loading, which is the application of force along the axis of an object. A practical example of this can be found in bridge truss members.
When a rod is under axial loading, the internal forces and corresponding stress are normal to the plane of the section, so it is termed normal stress. It's important to...
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The normal, a continuous distribution, is the most important of all the distributions. Its graph is a bell-shaped symmetrical curve, which is observed in almost all disciplines. Some of these include psychology, business, economics, the sciences, nursing, and, of course, mathematics. Some instructors may use the normal distribution to help determine students’ grades. Most IQ scores are normally distributed. Often real-estate prices fit a normal distribution. The normal distribution is...
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When a beam is subjected to different loads, such as weight, pressure, or other external forces, internal forces are generated within the beam. These forces can have a significant impact on the overall stability and strength of the structure. Engineers use various methods to analyze and determine the magnitude and direction of these internal forces. One common technique used to determine internal forces in beams is the method of sections. This method involves considering an imaginary point or...
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Related Experiment Video

Updated: Jan 23, 2026

Control of Eating Behavior Using a Novel Feedback System
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Normal lung development needs self-eating.

David Warburton1, Saverio Bellusci1,2

  • 1The Saban Research Institute, Children's Hospital Los Angeles, USC, Los Angeles, California, USA.

The Journal of Clinical Investigation
|June 5, 2019
PubMed
Summary

Autophagy, or "self-eating," is vital for lung development. Disrupting the beclin 1 gene in embryonic lung cells caused respiratory distress and impaired airway growth in mice.

Area of Science:

  • Cellular Biology
  • Developmental Biology
  • Physiology

Background:

  • Autophagy, a cellular process for homeostasis and disease regulation, is increasingly recognized for its broad physiological roles.
  • The specific role of intrinsic autophagy in lung development remains incompletely understood.

Purpose of the Study:

  • To investigate the necessity of intrinsic autophagy for normal lung development in embryonic mice.
  • To elucidate the cellular and developmental consequences of impaired autophagy in lung epithelial cells.

Main Methods:

  • Conditional deletion of the beclin 1 gene (Becn1) in lung epithelial cells of embryonic mice.
  • Assessment of neonatal survival, respiratory function, airway branching, and epithelial cell differentiation.

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Main Results:

  • Conditional deletion of Becn1 led to neonatal lethal respiratory distress.
  • Impaired autophagy significantly impacted airway branching and epithelial cell lineage differentiation.
  • The observed lung phenotype showed parallels with bronchopulmonary dysplasia in premature infants.

Conclusions:

  • Intrinsic autophagy is essential for normal lung development and airway maturation.
  • Autophagy deficiency in lung epithelial cells results in severe respiratory complications.
  • Targeting autophagy, potentially via cAMP-dependent kinase activation, may offer therapeutic avenues for lung developmental disorders.