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Related Experiment Video

Updated: Jan 23, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Monitoring, Switching, and Stopping Multiple Sclerosis Disease-Modifying Therapies.

Robert H Gross, John R Corboy

    Continuum (Minneapolis, Minn.)
    |June 5, 2019
    PubMed
    Summary

    Monitoring multiple sclerosis (MS) therapies is vital for long-term care. Early treatment and careful monitoring can reduce the need for switching disease-modifying therapies, improving patient outcomes.

    Area of Science:

    • Neurology
    • Immunology
    • Pharmacology

    Background:

    • Multiple sclerosis (MS) management involves numerous disease-modifying therapies (DMTs).
    • The increasing availability of highly effective immunotherapies complicates treatment decisions due to potential side effects.
    • Optimizing DMT selection and monitoring is crucial for long-term MS care.

    Observation:

    • Patients may switch or stop DMTs due to breakthrough disease, lack of compliance, or side effects.
    • Early initiation of effective, well-tolerated DMTs can minimize treatment changes.
    • Periodic clinical, radiographic, and laboratory monitoring is essential, tailored to the specific DMT.

    Findings:

    • Effective DMTs offer improved MS disease control but necessitate careful management of potential adverse events.

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  • Proactive patient support in navigating treatment decisions is a key aspect of MS care.
  • Ongoing monitoring is critical for sustained therapeutic benefit and patient safety.

    • Implications:

    • Personalized monitoring strategies are required for each DMT to maximize efficacy and minimize risks.
    • Shared decision-making between patients and providers is essential for treatment adherence and management.
    • Further research is needed to establish guidelines for the permanent discontinuation of DMTs in select MS patients.