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Negative Correlation between Serum Cytokine Levels and Cognitive Abilities in Children with Autism Spectrum Disorder
Daimei Sasayama1,2, Kana Kurahashi3, Kayoko Oda4
1Mental Health Clinic for Children, Shinshu University Hospital, Matsumoto 390-8621, Japan. sasayama@shinshu-u.ac.jp.
Journal of Intelligence
|June 5, 2019
Summary
Elevated levels of Interleukin-6 (IL-6) and Interferon-gamma (IFN-γ) are linked to lower cognitive abilities in children with autism spectrum disorder (ASD). This suggests cytokines may impact cognitive development in ASD.
Area of Science:
- Neuroscience
- Immunology
- Developmental Psychology
Background:
- Cytokines are implicated in cognitive development within autism spectrum disorder (ASD).
- Understanding the neural and cognitive mechanisms of ASD is crucial.
Purpose of the Study:
- To investigate the association between peripheral cytokine levels and cognitive profiles in children with ASD.
- To explore the role of specific cytokines in cognitive development in ASD.
Main Methods:
- Serum levels of 10 cytokines were measured in 14 children with ASD.
- Cognitive profiles were assessed using the Wechsler Intelligence Scale for Children (WISC).
- Statistical analyses examined correlations between cytokine levels and WISC scores.
Main Results:
- Full-scale IQ negatively correlated with Interleukin-6 (IL-6) levels (p < 0.0001).
- IL-6 and Interferon-gamma (IFN-γ) negatively correlated with verbal comprehension and working memory indices, respectively.
- No significant correlations were found for other measured cytokines.
Conclusions:
- IL-6 and IFN-γ levels are negatively associated with cognitive development in children with ASD.
- These findings support the hypothesis that cytokines influence neural development in ASD.
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