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Updated: Jan 23, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR
Michal Konrad Zarobkiewicz1, Wioleta Kowalska1, Miroslaw Slawinski2
1Chair and Department of Clinical Immunology, Medical University of Lublin, Lublin, Poland.
Abstract:
The aim of this paper was to summarise knowledge of IL-22 involvement in multiple sclerosis (MS) and the possible link between IL-22 and two transcription factors - AHR and c-Maf. The conclusion is that despite numerous studies, the exact role of IL-22 in the pathogenesis of MS is still unknown. The expression and function of c-Maf in MS have not been studied. It seems that the functions of c-Maf and AHR are at least partly connected with IL-22, as both directly or indirectly influence the regulation of IL-22 expression. This possible connection has never been studied in MS.
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