Related Experiment Video

Updated: Jan 23, 2026

The Mouse Isolated Perfused Kidney Technique
08:19

The Mouse Isolated Perfused Kidney Technique

Published on: November 17, 2016

23.2K

[Mechanisms of kidney damage]

A I Tarasenko1,2, A V Alekseev1,2, S Yu Maksimova1,2

  • 1) FGAOU VO I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Urologiia (Moscow, Russia : 1999)
|June 5, 2019
PubMed

Insights

This review details kidney damage mechanisms, focusing on immune system roles and molecular changes. It explores renal parenchyma restoration and fibrosis development after injury.

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Kidney damage involves complex mechanisms impacting renal tubule epithelium.
  • The immune system plays a critical role in the onset, progression, and resolution of kidney injury.
  • Molecular, genetic, and metabolic alterations significantly influence the severity and outcomes of renal trauma.

Purpose of the Study:

  • To review and synthesize recent findings on kidney damage mechanisms.
  • To elucidate the intricate role of the immune system in renal tubule injury.
  • To describe the processes of renal parenchyma repair and subsequent fibrosis.

Main Methods:

  • Literature review of recent studies on kidney damage.
  • Analysis of molecular, genetic, and metabolic pathways involved in renal injury.
  • Examination of immune system responses in the context of kidney damage.

Main Results:

  • Detailed description of immune system involvement in renal tubule damage.
  • Elucidation of molecular, genetic, and metabolic factors influencing injury extent and consequences.
  • Identification of mechanisms governing renal parenchyma restoration and fibrosis post-injury.

Conclusions:

  • Understanding immune and molecular mechanisms is key to addressing kidney damage.
  • The review provides insights into both injury processes and repair pathways.
  • Further research into these mechanisms can inform therapeutic strategies for kidney diseases.
Keywords:
cytokineskidney damagerenal fibrosis

More Related Videos

Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.3K
Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel08:23

Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel

Published on: October 13, 2018

10.9K

Related Concept Videos

Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.0K
Reaction Mechanisms03:06

Reaction Mechanisms

Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.6K
Mechanical Protein Functions01:58

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.5K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.1K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.0K
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
3.5K