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Updated: Jan 23, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

631

[Diabetic Kidney Disease - How to Protect the Kidney?]

Susanne Brenner1, Christoph Wanner1

  • 1Medizinische Klinik und Poliklinik 1, Schwerpunkte Kardiologie und Nephrologie, Universitätsklinikum Würzburg.

Deutsche Medizinische Wochenschrift (1946)
|June 5, 2019
PubMed

Insights

New diabetes therapies, including sodium glucose co-transporter 2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, offer significant cardio-renal protection beyond glycaemic control. Further advancements are expected with novel treatments targeting kidney disease progression.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Cardio-renal disease progression is a major burden in diabetes management.
  • Glycaemic control alone is insufficient for comprehensive diabetes care.
  • Emerging therapies offer cardiovascular and renal protective benefits.

Purpose of the Study:

  • To review current and emerging therapeutic strategies for managing cardio-renal complications in diabetes.
  • To highlight the roles of SGLT-2 inhibitors and GLP-1 receptor agonists.
  • To discuss novel agents for attenuating diabetic kidney disease progression.

Main Methods:

  • Review of clinical trial data and therapeutic concepts.
  • Comparative analysis of SGLT-2 inhibitors and GLP-1 receptor agonists.
  • Discussion of emerging treatments like finerenone and atrasentan.

Main Results:

  • SGLT-2 inhibitors and GLP-1 receptor agonists demonstrate significant reductions in cardiovascular events and renal disease progression.
  • Current evidence suggests SGLT-2 inhibitors may offer more pronounced benefits than GLP-1 receptor agonists.
  • Ongoing trials are exploring SGLT-2 inhibitors in advanced kidney disease.

Conclusions:

  • SGLT-2 inhibitors and GLP-1 receptor agonists represent key advancements in cardio-renal protection for diabetic patients.
  • Novel therapies targeting mineralocorticoid and endothelin-1 receptors are nearing finalization for diabetic kidney disease.
  • The future landscape of diabetes management will include multiple approaches to address cardio-renal complications.

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