Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human serum thymic factor in detecting acute T cell leukemia.

U Ozger Topuz, A O Cavdar, G Astaldi

    Bibliotheca Haematologica
    |January 1, 1978
    PubMed
    Summary

    This study investigated E+ cells in acute leukemia patients using the E rosette assay. Incubation with thymic factor increased E+ cells in some patients, suggesting potential for monitoring T cell variations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The bone marrow of pernicious anemia in in vitro culture.

    Gastroenterologia·2010
    Same author

    General considerations on tissue culture problems in hematological physiotherapy.

    Medecine et hygiene·2010
    Same author

    Research on the genesis of microerythrocytosis; comparative cytometric study of normal erythroblasts and Cooley disease.

    Policlinico infantile·2010
    Same author

    On the evaluation of the anti-pernicious activity of liver preparations based on the cell migration of guinea pig bone marrow explants.

    Il Farmaco, scienza e tecnica·2010
    Same author

    The anti-anemic-pernicious principle and the problem of its dosage.

    Il Farmaco, scienza e tecnica·2010
    Same author

    The problem of human leukemia: considerations on the results of bone marrow cultures in vitro.

    Le Sang·2010

    Area of Science:

    • Immunology
    • Hematology
    • Oncology

    Background:

    • Acute leukemia is a cancer of blood-forming tissues.
    • T cells play a crucial role in immune responses.
    • Immature T cell populations can be altered in leukemia.

    Purpose of the Study:

    • To investigate the frequency of E+ cells in acute leukemia patients.
    • To assess the effect of human serum thymic factor on E+ cell counts.
    • To explore the potential clinical utility of the E rosette assay in leukemia management.

    Main Methods:

    • E rosette assay was used to identify E+ cells.
    • Peripheral blood mononuclear cells from acute leukemia patients were analyzed.
    • Cells were incubated with human serum thymic factor before assay.

    Main Results:

    • E+ cells were quantified among mononuclear cells.
    • In 4 out of 24 patients, thymic factor incubation increased E+ cell frequency.
    • This suggests a potential interaction between thymic factor and T cell precursors.

    Conclusions:

    • The E rosette assay may help identify T cell abnormalities in acute leukemia.
    • Monitoring E+ cell variations could be relevant for treatment assessment.
    • The test might aid in understanding T cell dynamics during leukemia progression or remission.

    Related Experiment Videos