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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

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Use of idarucizumab in clinical practice: a case report

Libuše Husová

    Vnitrni Lekarstvi
    |June 6, 2019
    PubMed

    Insights

    Budd-Chiari syndrome can lead to liver cirrhosis, requiring anticoagulation with dabigatran. Idarucizumab, a dabigatran antidote, is crucial for managing coagulation during liver transplantation in these patients.

    Area of Science:

    • Hepatology
    • Transplant Surgery
    • Hematology

    Background:

    • Budd-Chiari syndrome is a serious hepatic vascular condition.
    • Chronic Budd-Chiari syndrome can progress to liver cirrhosis.
    • Anticoagulant therapy, including dabigatran, is indicated for Budd-Chiari syndrome.

    Observation:

    • Advanced liver cirrhosis may necessitate liver transplantation.
    • Dabigatran is an anticoagulant used in managing Budd-Chiari syndrome.
    • Idarucizumab serves as a specific antidote for dabigatran.

    Findings:

    • The case report details the first use of idarucizumab in a liver transplant patient with Budd-Chiari syndrome.
    • Idarucizumab facilitates coagulation adjustment and bleeding risk management.
    • This highlights the clinical utility of idarucizumab in complex transplant scenarios.

    Implications:

    • Idarucizumab is a valuable tool for managing patients on dabigatran undergoing liver transplantation.
    • This approach can improve outcomes for Budd-Chiari syndrome patients requiring liver transplants.
    • Further research into idarucizumab use in liver transplantation is warranted.

    Keywords:
    antidotebleedingdabigatrandirect oral anticoagulants (DOAC)idarucizumabliver transplant

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