GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

Niamh Mullins¹, Tim B Bigdeli¹, Anders D Børglum¹+123

• ¹Social Genetic and Developmental Psychiatry Centre, King's College London (Mullins, Coleman, R.A. Mehta, Breen, McGuffin, Lewis); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York (Mullins, Stahl, Sklar); Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, (Bigdeli, Fanous); Department of Psychiatry, Virginia Commonwealth University, Richmond, Va. (Bigdeli, Fanous, Kendler); Department of Biomedicine, Aarhus University, Aarhus, Denmark (Børglum, Demontis, Starnawska); iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark (Børglum, Demontis, Starnawska, Mortensen); iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark (Børglum, Demontis, Starnawska, Hougaard, Agerbo, Nordentoft, Mors, Mortensen, Hansen, Werge, Appadurai); Queensland Brain Institute, the University of Queensland, Brisbane, Queensland, Australia (D. Mehta, Wray); School of Psychology and Counseling, Queensland University of Technology, Brisbane, Queensland, Australia (D. Mehta); Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston (Ripke, Lee); Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany (Ripke); Medical and Population Genetics, Broad Institute, Cambridge, Mass. (Ripke, Stahl); Department of Psychiatry and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York (Stahl, Sklar, Kahn); Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, U.K. (Anjorin); Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland (Corvin); Department of Psychiatry and Behavioral Neuroscience, University of Chicago (Sanders, Gejman); Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, Ill. (Sanders, Gejman); Department of Psychiatry (UPK), University of Basel, Basel, Switzerland (Forstner); Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland (Forstner, Hoffmann, Cichon); Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland (Forstner); Institute of Human Genetics, University of Bonn, Germany (Forstner, Koller, Degenhardt, Nöthen, Hoffmann, Cichon); Life and Brain Center, Department of Genomics, University of Bonn, Germany (Forstner, Koller, Degenhardt, Nöthen, Hoffmann); Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany (Reif); Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland (Świątkowska); Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Australia (Baune); Department of Psychiatry, University of Münster, Münster, Germany (Baune); University of Liverpool, Liverpool, U.K. (Müller-Myhsok); Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany (Müller-Myhsok, Binder); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (Müller-Myhsok); Department of Psychiatry, University of Halle, Halle, Germany (Rujescu, Giegling); Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, the Netherlands (Penninx, Milaneschi); College of Medicine Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, New York (C. Pato); Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, New York (C. Pato, M.T. Pato); Centre for Addiction and Mental Health, Toronto (Zai, Vincent, Strauss, Kloiber); Department of Psychiatry, University of Munich, Munich, Germany (Rujescu, Giegling); Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark (Hougaard); Department of Psychiatry, University of Oxford, Oxford, U.K. (Quested); Psychiatry & Behavioral Sciences, Stanford University, Stanford, Calif. (Levinson); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Ga. (Binder); Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia (Byrne, Trzaskowski, Wray); Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark (Agerbo, Mortensen); National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark (Agerbo, Mortensen); Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Streit, Strohmaier, Schulze); Mental Health Department, University Regional Hospital. Biomedicine Institute (IBIMA), Málaga, Spain (Mayoral, Guzman-Parra); Department of Psychiatry and Addiction Medicine, Assistance Publique-Hôpitaux de Paris, Paris (Bellivier, Leboyer); Paris Bipolar and TRD Expert Centres, FondaMental Foundation, Paris (Bellivier); UMR-S1144 Team 1: Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris (Bellivier); Psychiatry, Université Paris Diderot, Paris (Bellivier); NIHR Maudsley Biomedical Research Centre, King's College London (Breen); Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology-NTNU, Trondheim, Norway (Morken); Psychiatry, St. Olavs University Hospital, Trondheim, Norway (Morken); Department of Psychiatry, McGill University, Montreal (Turecki); Department of Neurology and Neurosurgery, McGill University, Faculty of Medicine, Montreal. (Rouleau); Montreal Neurological Institute and Hospital (Rouleau); Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany (Grabe, Van der Auwera); Institute for Community Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany (Völzke); Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, U.K. (Jones, Hamshere, O'Donovan, Owen, Craddock); Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway (Agartz); NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Norway (Agartz); Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden (Agartz); Division of Mental Health and Addiction, Oslo University Hospital (Melle); Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo (Melle); Psychiatry, North East London NHS Foundation Trust, Ilford, U.K. (Lawrence); MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, U.K. (Walters); Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Md. (Shi); Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland (Hauser); Health Sciences Research, Mayo Clinic, Rochester, Minn. (Biernacka); Department of Psychiatry, University of California San Diego, La Jolla, Calif. (Kelsoe); Department of Psychiatry, University of Toronto (Strauss, Kloiber); Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland (Lissowska); Division of Psychiatry, University College London (Pimm, Bass, McQuillin); Department of Psychiatry, Massachusetts General Hospital, Boston (Smoller); Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston Smoller); Stanley Center for Psychiatric Research, Broad Institute, Cambridge, Mass (Smoller, Lee); Institute of Epidemiology and Social Medicine, University of Münster, Münster, Nordrhein-Westfalen, Germany (Berger); Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor (Scott, Boehnke); Department of Psychological Medicine, University of Worcester, Worcester, U.K. (Jones); Department of Psychiatry, University of Coimbra, Coimbra, Portugal (Azevedo); Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (Kogevinas); Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany (Rietschel); Psychiatry, UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, the Netherlands (Boks, Kahn); Max Planck Institute of Psychiatry, Munich, Germany (Ising, Kloiber, Lucae); Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania (Grigoroiu-Serbanescu); Faculté de Médecine, Université Paris Est, Créteil, France (Leboyer, Jamain); INSERM, Paris (Leboyer); Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minn. (Frye); Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada (Alda); National Institute of Mental Health, Klecany, Czech Republic (Alda); Department of Psychiatry, University Hospital of Lausanne, Prilly, Vaud, Switzerland (Preisig); Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark (Nordentoft); Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia (Renteria); Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Munich, Germany (Budde, Schulze); Psychiatry, Columbia University College of Physicians and Surgeons, New York (Weissman, McGrath); Division of Epidemiology, New York State Psychiatric Institute, New York (Weissman); Department of Neurosciences, University of California San Diego, La Jolla, Calif. (Smeland); Division of Mental Health and Addiction, Oslo University Hospital (Smeland, Andreassen); NORMENT, University of Oslo (Smeland, Andreassen); Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, Denmark (Mors); Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York (Sklar); Department of Biomedicine, University of Basel, Basel, Switzerland (Hoffmann, Cichon); Psychiatric and Neurodevelopmental Genetics Unit, Mass. General Hospital, Boston (Lee); Jane and Terry Semel Institute for Neuroscience and Human Behavior, Los Angeles (Ophoff); UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, the Netherlands (Ophoff); Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden (Adolfsson); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Norway (Djurovic); Department of Medical Genetics, Oslo University Hospital Ullevål, (Djurovic); Department of Biomedicine, University of Basel, Basel, Switzerland (Heilmann-Heimbach); Psychiatrie Translationnelle, Inserm U955, Créteil, France (Jamain); Psychiatry, Kaiser Permanente Northern California, San Francisco (Hamilton); Research Institute, Lindner Center of HOPE, Mason, Ohio, (McElroy); Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany (Cichon); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Md. (Schulze); Human Genetics Branch, Intramural Research Program, NIMH, Bethesda, Md. (Schulze); Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, Niedersachsen, Germany (Schulze); Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen (Hansen); Department of Clinical Medicine, University of Copenhagen (Werge); Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark (Werge); Discipline of Psychiatry, University of Adelaide, Adelaide, Australia (Air); Psychiatry and Human Genetics, University of Pittsburgh (Nimgaonkar); Department of Psychiatry, UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, the Netherlands (Cahn); Department of Medical & Molecular Genetics, King's College London (Lewis).