Related Experiment Video
Updated: Jan 23, 2026

Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 23, 2013
Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019
Kaisu Rantakokko-Jalava1,2, Kati Hokynar3, Niina Hieta4,2
1Department of Clinical Microbiology, Turku University Hospital, Turku, Finland.
Abstract:
Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known.
Related Concept Videos
SI Units: 2019 Redefinition
A standard set of units has been defined...
False Memories
One primary source of false memories is misattribution, where individuals incorrectly associate external information...
Bacterial Phylum Chlamydiae
Negative Regulator Molecules
Positive, Negative, and Zero Work
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

