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Updated: Jan 23, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Ultrasound-assisted synthesis of heterocyclic compounds
Ghodsi Mohammadi Ziarani1, Zohreh Kheilkordi2, Parisa Gholamzadeh2
1Department of Chemistry, Alzahra University, Vanak Square, P.O. Box 1993893973, Tehran, Iran. gmziarani@hotmail.com.
Abstract:
In this review, we tried to underscore the synthesis of the heterocyclic compounds under assisted ultrasonic irradiation. The ultrasonic irradiation has been applied for medicinal chemistry and drug discovery process since it dramatically reduces reaction times, from days or hours to minutes. Also, ultrasonic irradiation provides lower cost, excellent yields, greater purity, and simple workups as compared to lower yields, longer reaction times, lesser purity and in the conventional methods. In this review, we have compared synthesis of the heterocyclic compounds under ultrasonic irradiation with other methods.
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