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Reduced risk of stroke following cholecystectomy: A nationwide population-based study

Cheng-Yu Wei1,2,3, Shu-Hung Chuang4,5, Cheng-Li Lin6

  • 1Department of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.

Journal of Gastroenterology and Hepatology
|June 6, 2019
PubMed

Insights

Cholecystectomy, or gallstone removal, significantly reduces the risk of overall, ischemic, and hemorrhagic stroke in patients with gallstones. This surgical intervention offers a protective effect against stroke development.

Area of Science:

  • Gastroenterology
  • Neurology
  • Public Health

Background:

  • Gallstones and stroke are prevalent global health issues.
  • Existing literature suggests a link between gallstones and stroke.
  • This study investigates stroke risk in gallstone patients undergoing cholecystectomy.

Purpose of the Study:

  • To assess the impact of cholecystectomy on stroke risk in gallstone patients.
  • To compare stroke incidence between gallstone patients with and without gallbladder removal.
  • To characterize stroke risk stratification following gallstone treatment.

Main Methods:

  • A nationwide, population-based, retrospective cohort study.
  • Utilized data from Taiwan's National Health Insurance Research Database.
  • Analyzed 155,356 gallstone patients, comparing those with and without cholecystectomy.

Main Results:

  • Cholecystectomy significantly decreased the risk of overall stroke (HR=0.60), ischemic stroke (HR=0.59), and hemorrhagic stroke (HR=0.56).
  • Patients with gallstones experienced lower stroke risks post-cholecystectomy, regardless of symptom presentation.
  • Stroke incidence was 17.8/1000 person-years without cholecystectomy and 10.6/1000 person-years with cholecystectomy.

Conclusions:

  • Cholecystectomy is associated with a reduced risk of all stroke types in gallstone patients.
  • The findings support considering cholecystectomy as a stroke-preventive measure.
  • Gallstone patients, especially those with stroke risk factors, may benefit from preventive strategies.
Abstract

Keywords:
cholecystectomycholelithiasisgallstone diseasegallstonesstroke

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