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Matrix metalloproteinases and ADAMs in stroke
Joan Montaner1, Laura Ramiro2, Alba Simats2
1Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain. 31862jmv@comb.cat.
Cellular and Molecular Life Sciences : CMLS
|June 6, 2019
Summary
Matrix metalloproteinases (MMPs) and ADAMs are key players in stroke-related brain injury and repair. Understanding their roles may lead to new neuroprotective therapies and biomarkers for stroke patients.
Area of Science:
- Neuroscience
- Biochemistry
- Pathology
Background:
- Stroke remains a significant global health challenge with incompletely understood pathophysiology.
- Matrix metalloproteinases (MMPs) and ADAMs are increasingly recognized for their roles in the neuro-inflammatory cascade during stroke and its recovery phases.
Purpose of the Study:
- To review the involvement of MMPs and ADAMs in cerebral ischemia-induced brain injury.
- To explore their implications in neurorepair mechanisms and neuroprotective therapies.
- To discuss their role in specific neurovascular diseases and potential as biomarkers.
Main Methods:
- Literature review of recent research on MMPs and ADAMs in stroke.
- Analysis of studies investigating neuroprotection and neurorepair involving these protein families.
- Examination of their involvement in small vessel diseases and intracerebral hemorrhage.
Main Results:
- MMPs and ADAMs are implicated in both the acute injury and subsequent recovery phases of stroke.
- Modulating MMPs and ADAMs shows potential for neuroprotective strategies.
- These proteins play a role in specific neurovascular conditions like small vessel diseases and intracerebral hemorrhage.
Conclusions:
- MMPs and ADAMs are critical in stroke pathophysiology, influencing both injury and repair.
- Targeting MMPs and ADAMs offers therapeutic potential for stroke.
- These proteins may serve as valuable biomarkers for assessing brain injury and guiding stroke treatment decisions.
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