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Matrix metalloproteinases and ADAMs in stroke

Joan Montaner1, Laura Ramiro2, Alba Simats2

  • 1Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain. 31862jmv@comb.cat.

Cellular and Molecular Life Sciences : CMLS
|June 6, 2019
PubMed

Insights

Matrix metalloproteinases (MMPs) and ADAMs are key players in stroke-related brain injury and repair. Understanding their roles may lead to new neuroprotective therapies and biomarkers for stroke patients.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Stroke remains a significant global health challenge with incompletely understood pathophysiology.
  • Matrix metalloproteinases (MMPs) and ADAMs are increasingly recognized for their roles in the neuro-inflammatory cascade during stroke and its recovery phases.

Purpose of the Study:

  • To review the involvement of MMPs and ADAMs in cerebral ischemia-induced brain injury.
  • To explore their implications in neurorepair mechanisms and neuroprotective therapies.
  • To discuss their role in specific neurovascular diseases and potential as biomarkers.

Main Methods:

  • Literature review of recent research on MMPs and ADAMs in stroke.
  • Analysis of studies investigating neuroprotection and neurorepair involving these protein families.
  • Examination of their involvement in small vessel diseases and intracerebral hemorrhage.

Main Results:

  • MMPs and ADAMs are implicated in both the acute injury and subsequent recovery phases of stroke.
  • Modulating MMPs and ADAMs shows potential for neuroprotective strategies.
  • These proteins play a role in specific neurovascular conditions like small vessel diseases and intracerebral hemorrhage.

Conclusions:

  • MMPs and ADAMs are critical in stroke pathophysiology, influencing both injury and repair.
  • Targeting MMPs and ADAMs offers therapeutic potential for stroke.
  • These proteins may serve as valuable biomarkers for assessing brain injury and guiding stroke treatment decisions.
Keywords:
ADAMBiomarkerMMPNeuroprotectionNeurorepairStroke

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