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IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT

Sofia Alexandra Pereira Pires1, Ana Pereira Lemos2, Ester Preciosa Maio Nunes Pereira2

  • 1Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo
|June 6, 2019
PubMed
Abstract

Insights

Ibuprofen can cause drug-induced aseptic meningitis (DIAM) in adolescents, a rare condition. Early recognition and drug withdrawal are crucial for recovery and preventing recurrence of this ibuprofen side effect.

Area of Science:

  • Neurology
  • Pediatrics
  • Pharmacology

Background:

  • Drug-induced aseptic meningitis (DIAM) is a rare but serious adverse reaction.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, are common culprits.
  • DIAM is infrequently reported in pediatric populations.

Observation:

  • A 15-year-old male presented with acute symptoms including headache, fever, and blurred vision shortly after ibuprofen ingestion.
  • Neurological signs such as neck stiffness and emesis developed during observation.
  • Cerebrospinal fluid analysis ruled out infectious meningitis.

Findings:

  • The patient was diagnosed with ibuprofen-induced aseptic meningitis.
  • Complete recovery was achieved after discontinuing ibuprofen.
  • A temporal relationship between ibuprofen intake and symptom onset was noted.

Implications:

  • DIAM should be considered in the differential diagnosis of aseptic meningitis, especially in adolescents.
  • Prompt identification and withdrawal of the offending NSAID are essential for patient management.
  • Awareness of DIAM can prevent misdiagnosis and unnecessary treatments.

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