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Updated: Jan 23, 2026
08:56
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
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IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT.
Sofia Alexandra Pereira Pires1, Ana Pereira Lemos2, Ester Preciosa Maio Nunes Pereira2
1Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Summary
Ibuprofen can cause drug-induced aseptic meningitis (DIAM) in adolescents, a rare condition. Early recognition and drug withdrawal are crucial for recovery and preventing recurrence of this ibuprofen side effect.
Area of Science:
- Neurology
- Pediatrics
- Pharmacology
Background:
- Drug-induced aseptic meningitis (DIAM) is a rare but serious adverse reaction.
- Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, are common culprits.
- DIAM is infrequently reported in pediatric populations.
Observation:
- A 15-year-old male presented with acute symptoms including headache, fever, and blurred vision shortly after ibuprofen ingestion.
- Neurological signs such as neck stiffness and emesis developed during observation.
- Cerebrospinal fluid analysis ruled out infectious meningitis.
Findings:
- The patient was diagnosed with ibuprofen-induced aseptic meningitis.
- Complete recovery was achieved after discontinuing ibuprofen.
- A temporal relationship between ibuprofen intake and symptom onset was noted.
Implications:
- DIAM should be considered in the differential diagnosis of aseptic meningitis, especially in adolescents.
- Prompt identification and withdrawal of the offending NSAID are essential for patient management.
- Awareness of DIAM can prevent misdiagnosis and unnecessary treatments.
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