Serum 25(OH)D levels after oral vitamin D₃ supplementation and UVB exposure correlate

The inter-individual variation in 25(OH)D₃ increase (Δ25(OH)D₃ ) after vitamin D₃ supplementation was determined and compared with the UVB irradiation response.

Nineteen Danish participants received 85 μg vitamin D₃ (cholecalciferol) daily for nine weeks with regular serum 25(OH)D₃ measurements. These participants had three years earlier taken part in a 9-week controlled UVB study. The Δ25(OH)D₃ was not confounded by ambient UVB, BMI or ethnicity.

Δ25(OH)D₃ was 53 nmol L^-1 and almost identical to Δ25(OH)D₃ (52 nmol L^-1 ) after UVB. Δ25(OH)D₃ ranged from 17 to 91 nmol L^-1 (span 74 nmol L^-1 ) and was about half of that observed after UVB irradiation (span 136 nmol L^-1 ). The interquartile ranges for vitamin D₃ supplementation (38.8-71.4 nmol L^-1 , span: 32.6 nmol L^-1 ) and UVB irradiation (35.7-65.4 nmol L^-1 , span: 29.7 nmol L^-1 ) were similar indicating a comparable response of the two interventions. As the 25(OH)D₃ start levels (R²  = 0.398, P = 3.8 × 10^-3 ), 25(OH)D₃ end levels (R²  = 0.457, P = 1.5 × 10^-3 ) and Δ25(OH)D₃ (R²  = 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D₃ -induced and UVB-induced Δ25(OH)D₃ . A combined model including the influence of these four SNPs and the 25(OH)D₃ start level explained 86.8% (P = 1.6 × 10^-35 ) of the individual variation after vitamin D₃ supplementation.

The inter-individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background.