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Related Experiment Video

Updated: Jan 23, 2026

Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Genome Editing in Mammalian Cell Lines using CRISPR-Cas

Published on: April 11, 2019

How Does the Regulatory Genome Work?

Sorin Istrail¹, Isabelle S Peter²

¹Department of Computer Science, Brown University, Providence, Rhode Island.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology

|June 6, 2019

Summary

This summary is machine-generated.

The regulatory genome processes complex information to control gene activity. This study details two sea urchin embryo examples of gene regulatory systems, analyzed using computational logic models for systems-level understanding.

Keywords:

Boolean modeling developmental gene regulation gene regulatory networks sea urchin

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Genome Editing in Mammalian Cell Lines using CRISPR-Cas

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Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

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Area of Science:

Genomics
Developmental Biology
Computational Biology

Background:

The regulatory genome is crucial for controlling gene expression throughout an organism's life.
Understanding the regulatory genome requires dissecting complex information processing functions.
The sea urchin embryo serves as a model system for studying early development and gene regulation.

Purpose of the Study:

To experimentally dissect and computationally model regulatory functions within the genome.
To assess distinct organizational levels of genomic information processing.
To provide systems-level insights into how the regulatory genome operates.

Main Methods:

Experimental dissection of gene regulatory systems.
Development of computational logic models.
Systems-level analysis of genomic information processing.

Main Results:

Detailed analysis of two distinct regulatory functions in the sea urchin embryo.
Formalization of regulatory mechanisms using computational logic.
Demonstration of systems-level understanding of gene regulation.

Conclusions:

The regulatory genome performs complex information processing essential for organismal development.
Experimental and computational approaches can elucidate gene regulatory mechanisms.
The sea urchin embryo provides a valuable model for studying fundamental aspects of genomic regulation.