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Updated: Jan 23, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
[Systemic Therapy of Metastatic Colorectal Cancer]
Dominik Paul Modest1, Michael von Bergwelt-Baildon1
1Medizinische Klinik und Poliklinik III, Campus Großhadern (LMU), Klinikum der Universität München, Deutschland.
Abstract:
The successful management of metastatic colorectal cancer (mCRC) is an interdisciplinary challenge, involving medical oncology, surgery and also interventional specialists. Systemic therapy of mCRC is based on regimens of chemotherapeutic combinations plus monoclonal antibodies targeting EGFR and VEGF. EGFR-directed antibodies can guided by biomarkers, namely RAS mutation and sidedness of the primary tumor. In pretreated patients, several targetable molecular markers (i.e. BRAF mutation, MSI-status and Her2) should be tested. BRAF inhibitors, checkpoint-inhibitors and her2-targeted combinations (although off-label therapy) increase the available therapeutic options in these selected subgroups.
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