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FAIM: An Antagonist of Fas-Killing and Beyond

Jianxin Huo1, Shengli Xu2,3, Kong-Peng Lam4,5,6

  • 1Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668, Singapore. huo_jianxin@bti.a-star.edu.sg.

Cells
|June 7, 2019
PubMed

Insights

Fas Apoptosis Inhibitory Molecule (FAIM) is an anti-apoptotic protein. This review summarizes FAIM

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Neuroscience

Background:

  • Fas Apoptosis Inhibitory Molecule (FAIM) is an anti-apoptotic protein.
  • FAIM is upregulated in B cell receptor (BCR)-activated B cells, conferring resistance to Fas-mediated cell death.
  • Two alternatively spliced isoforms exist: short (ubiquitous) and long (nervous tissues).

Purpose of the Study:

  • To comprehensively review the diverse functions of FAIM.
  • To discuss the molecular mechanisms underlying FAIM's roles.
  • To explore FAIM's potential as a diagnostic, prognostic, or therapeutic target.

Main Methods:

  • Literature review of studies on FAIM.
  • Analysis of FAIM's evolutionary conservation and homology.
  • Synthesis of findings across various physiological and pathological contexts.

Main Results:

  • FAIM's primary role is anti-apoptotic.
  • Additional functions identified in cell growth, metabolism, Alzheimer's disease, and tumorigenesis.
  • Detailed molecular mechanisms remain largely unknown.

Conclusions:

  • FAIM plays multifaceted roles beyond apoptosis.
  • Further research is needed to elucidate molecular mechanisms.
  • FAIM holds potential as a target for diagnostics, prognostics, and therapeutics.
Keywords:
AktAlzheimer’s diseaseB cellsFAIMFas-mediated apoptosisMultiple myelomaTCR-mediated apoptosisc-FLIPmetabolism

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