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ABH and Lewis antigen and antibody expression after bone marrow transplantation
M E Needs1, D M McCarthy, J Barrett
1Department of Haematology, Westminster Hospital, London, UK.
Acta Haematologica
|January 1, 1987
Abstract:
We have tested 10 bone marrow transplant donors and recipients for ABH and Lewis antigens and ABH antibodies. Two group A2 recipients stably engrafted with group O marrow produced anti-A1. Small quantities of recipient-type ABH substance were found on the posttransplant erythrocytes in cases where the recipient was a secretor but not in a single nonsecretor recipient. Lewis antigens were always of recipient type. The incidence of graft-versus-host disease and graft rejection were similar in 41 patients who received ABO-mismatched and 61 patients who received ABO-matched grafts.