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Published on: August 16, 2017
PRIMARY EPITHELIOID HEMANGIOENDOTHELIOMA IN THE CEREBELLUM: CASE REPORT WITH REFERENCE TO DRASTIC CHANGE IN THE WHO
Ibrahim Omerhodžić1, Nurija Bilalović1, Bekir Rovčanin1
11Department of Neurosurgery, University Clinical Center of Sarajevo, Sarajevo, Bosnia-Herzegovina; 2Department of Clinical Pathology and Cytology, University Clinical Center of Sarajevo, Sarajevo, Bosnia-Herzegovina; 3School of Medicine, University of Sarajevo, Sarajevo, Bosnia-Herzegovina; 4Department of Radiology, Sarajevo General Hospital, Sarajevo, Bosnia-Herzegovina; 5Department of Neurology, University Clinical Center of Sarajevo, Sarajevo, Bosnia-Herzegovina; 6Department of Neurosurgery, Dubrava University Hospital, Zagreb, Croatia; 7Semmes-Murphey Clinic and University of Tennessee, Memphis, TN, USA.
Abstract:
- Epithelioid hemangioendothelioma is a rare vascular brain tumor. It develops from endothelial cells, usually in the liver, lung, bone and soft tissue. Primary localization of this tumor in the intracranial space is very uncommon; only 47 cases have been described in the literature. This tumor was initially classified as grade I (benign) in the World Health Organization (WHO) 2007 classification. In 2016, this tumor was re-classified as grade III (malignant). Herein, the first case report of epithelioid hemangioendothelioma in the cerebellum of a male patient is presented. Complete surgical excision was done. No adjuvant therapy was administered. Magnetic resonance imaging performed 2 years after the surgery continued to show no recurrence of the tumor. To our knowledge, this is the first report of cerebellar location of this rare tumor. In addition, the authors report drastic re-classification of the epithelioid hemangioendothelioma from the benign tumor (WHO 2007) to a malignant one (2016), which significantly changes postoperative management and follow up of this brain neoplasm.
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