Circadian Clock Genes in Diabetic Kidney Disease (DKD)

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Updated: Jan 23, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

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Olanrewaju A Olaoye1, Sarah H Masten1, Rajesh Mohandas1,2

  • 1Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, 1600 SW Archer Road, Box 100224, Gainesville, FL, 32610, USA.

Current Diabetes Reports
|June 7, 2019
PubMed
Abstract

Insights

This review summarizes current knowledge on circadian rhythms and normal kidney function. It explores potential links between the body clock and diabetic kidney disease development, using human and rodent data.

Area of Science:

  • Nephrology
  • Chronobiology
  • Metabolic Diseases

Background:

  • Circadian rhythms play a crucial role in regulating normal physiological processes, including renal function.
  • Disruptions in circadian rhythms are increasingly implicated in various pathologies.
  • Diabetic kidney disease (DKD) is a major complication of diabetes mellitus, characterized by progressive renal damage.

Purpose of the Study:

  • To review the current understanding of circadian rhythm's role in normal kidney function.
  • To investigate the potential contribution of circadian clock mechanisms to the pathogenesis of diabetic kidney disease.
  • To hypothesize mechanisms linking circadian clock function and kidney disease in diabetes.

Main Methods:

  • Literature review of existing studies on circadian rhythms and renal function.
  • Analysis of recent findings in diabetic kidney disease research.
  • Integration of data from human and rodent models to identify potential mechanistic links.

Main Results:

  • Established knowledge on circadian regulation of normal renal function is summarized.
  • Recent findings highlight potential connections between DKD mechanisms and the circadian clock.
  • Hypothesized mechanisms suggest a role for circadian disruption in DKD development.

Conclusions:

  • Circadian rhythms are integral to normal kidney function.
  • A significant knowledge gap exists regarding the role of circadian clock mechanisms in DKD.
  • Further research is warranted to elucidate the specific links between circadian disruption and diabetic kidney disease progression.
Keywords:
BMAL1Circadian rhythmHIFRenal functionShift work

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