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Related Experiment Videos

Framework invasion by laryngeal carcinoma.

R T Gregor1, K Hammond

  • 1Department of Otolaryngology, University of Witwatersrand School of Medicine, Johannesburg, South Africa.

American Journal of Surgery
|October 1, 1987
PubMed
Summary

Cancer invasion of laryngeal cartilage occurs in ossified or calcified areas. This spread is linked to tumor-produced alkaline phosphatase and bone-building activity, explaining CT scan findings.

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Area of Science:

  • Oncology
  • Pathology
  • Biochemistry

Background:

  • Laryngeal cancer invasion into the framework affects prognosis.
  • Invasion typically occurs in ossified or calcified cartilage, a mechanism previously unexplained.
  • Increased density on CT scans during invasion prompted this investigation.

Purpose of the Study:

  • To elucidate the mechanisms of laryngeal framework invasion by cancer.
  • To investigate the role of cartilage ossification and calcification in tumor spread.
  • To identify biochemical markers associated with invasion.

Main Methods:

  • Examination of 158 laryngeal specimens using serial sectioning.
  • Analysis of alkaline phosphatase and collagenase in laryngeal tissues.
  • Tetracycline labeling to assess osteoblastic activity in selected specimens.

Main Results:

  • Framework invasion predominantly occurred at the glottic level and exclusively in ossified/calcified cartilage.
  • Invasion correlated with osteoblastic activity, potentially mediated by tumor-produced alkaline phosphatase.
  • Concurrent osteoclastic activity was observed, with the tumor remaining outside the perichondrium.

Conclusions:

  • Laryngeal cancer invades ossified or calcified cartilage via mechanisms involving osteoblastic and osteoclastic activity.
  • Tumor-produced alkaline phosphatase likely plays a role in mediating this invasion.
  • Tetracycline labeling confirmed active bone deposition, explaining CT scan observations of increased ossification during early invasion.

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