Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Statistical Significance01:50

Statistical Significance

21.2K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
21.2K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.3K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.3K
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

41.1K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
41.1K
Significance of Center of Mass01:12

Significance of Center of Mass

7.6K
The center of mass of an object is defined as the mass-weighted average position of all the particles that comprise the object. The significance of the center of mass of an object can be seen by looking at its dynamics. The time derivative of the center of mass gives its velocity, assuming that the object's mass remains constant over time. Furthermore, the total linear momentum of an object can be seen as the linear momentum of a single particle of the object's total mass moving with...
7.6K
Significance Testing: Overview01:04

Significance Testing: Overview

11.6K
Significance testing is a set of statistical methods used to test whether a claim about a parameter is valid. In analytical chemistry, significance testing is used primarily to determine whether the difference between two values comes from determinate or random errors. The effect of a particular change in the measurement protocol, analyst, or sample itself can cause a deviation from the expected result. In the case of a suspected deviation/outlier, we need to be able to confirm mathematically...
11.6K
Significance of Displacement Current01:27

Significance of Displacement Current

5.8K
A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sympathectomy aggravates subchondral bone changes during osteoarthritis progression in mice without affecting cartilage degeneration or synovial inflammation.

Osteoarthritis and cartilage·2021
Same author

Comparison of Gait Symmetry and Joint Moments in Unilateral and Bilateral Hip Osteoarthritis Patients and Healthy Controls.

Frontiers in bioengineering and biotechnology·2021
Same author

Combined extra-/intrathoracic correction of pectus carinatum and other asymmetric chest wall deformities : A novel technique.

Operative Orthopadie und Traumatologie·2018
Same author

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix.

Osteoarthritis and cartilage·2017
Same author

[Skeletal hemangiomas].

Der Orthopade·2017
Same author

[EOS imaging acquisition system : 2D/3D diagnostics of the skeleton].

Der Orthopade·2015

Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.4K

[Growing Pains : Cause, Significance and Treatment].

S Adolf1, S Braun, A Meurer

  • 1Orthopädische Universitätsklinik Friedrichsheim, Marienburgstr. 2, 60528, Frankfurt am Main, Deutschland. stefanie.adolf@friedrichsheim.de.

Der Orthopade
|June 7, 2019
PubMed
Summary

Growing pains in children are common and typically benign, often occurring at night. While the exact cause is unknown, management focuses on reassurance and non-medicinal therapies like massage and stretching.

Keywords:
Bone cancerLower extremityMusculoskeletal painOsteomyelitisPediatrics

More Related Videos

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

8.8K
Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding
02:41

Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding

Published on: May 3, 2024

2.2K

Related Experiment Videos

Last Updated: Jan 23, 2026

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.4K
Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

8.8K
Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding
02:41

Author Spotlight: Enhancing Women's Chronic Pelvic Pain Management Through Acupoint Catgut Embedding

Published on: May 3, 2024

2.2K

Area of Science:

  • Pediatric Orthopedics
  • Pediatric Rheumatology

Background:

  • Leg pain is a frequent pediatric orthopedic consultation reason, affecting various age groups, primarily preschool and elementary school children.
  • Severe differential diagnoses necessitate thorough patient history and physical examination for children presenting with leg pain.

Purpose of the Study:

  • To elucidate the unknown causes of benign growing pains in children.
  • To explore potential anatomical, metabolic, or functional factors contributing to growing pains.
  • To outline diagnostic and therapeutic strategies for managing childhood leg pain.

Main Methods:

  • Growing pains are diagnosed by exclusion, requiring extended evaluation if organic causes are suspected.
  • Characterized by nocturnal occurrence and spontaneous resolution.
  • Treatment involves mild analgesics for severe cases, but emphasizes parental education on the benign nature of the condition.

Main Results:

  • The exact etiology of benign growing pains remains unelucidated despite extensive research.
  • Multiple theories suggest anatomical, metabolic, or functional factors.
  • Non-pharmacological interventions such as reassurance, relaxation exercises, massage, and stretching significantly reduce pain.

Conclusions:

  • Growing pains are a benign, self-resolving condition primarily diagnosed by exclusion.
  • Effective management relies on parental reassurance and non-medicinal therapies.
  • Further research into the underlying causes may refine understanding and treatment approaches.