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Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

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Related Experiment Video

Updated: Jan 23, 2026

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

Autoimmunity in 2018.

Carlo Selmi^1,2

¹Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center - IRCCS -, via A. Manzoni 56, 20089, Rozzano, Milan, Italy. carlo.selmi@humanitas.it.

Clinical Reviews in Allergy & Immunology

|June 7, 2019

Summary

This summary is machine-generated.

Autoimmunity research remains a rapidly growing field within immunology, with consistent publication numbers and a focus on shared mechanisms across diseases. Advances in understanding Th17 cells, cytokines, and the microbiome offer promising therapeutic developments.

Keywords:

Autoantibody Immune checkpoint inhibitors Th17 Tolerance

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Area of Science:

Immunology
Autoimmunity Research

Background:

Autoimmunity research publications in 2018 mirrored 2017 levels, maintaining over 5% of the immunology field share.
A review of major immunology and autoimmunity journals over 12 years highlights common mechanisms across autoimmune diseases.

Purpose of the Study:

To discuss major themes in autoimmunity research based on recent publications.
To highlight similarities in pathogenic mechanisms among various autoimmune diseases.

Main Methods:

PubMed search for "autoimmunity" in major immunology and autoimmunity journals.
Arbitrary discussion of encountered themes in peer-reviewed articles.

Main Results:

Similarities in autoimmune disease mechanisms significantly outweigh differences, involving factors like Th17 cells, cytokines (e.g., IL-10, IFN), BLIMP-1, and NF-kB.
The microbiome, epigenetics, and long non-coding RNA are central to autoimmunity development, with increasing data across conditions.
Specific diseases like systemic lupus erythematosus, rheumatoid arthritis, and psoriatic arthritis show encouraging findings linking basic and clinical science.

Conclusions:

Autoimmunity is a rapidly advancing scientific field, growing faster than many other areas of immunology.
The strong connection between basic and clinical research, coupled with a robust rheumatology therapeutic pipeline, offers hope for improved patient treatment.