Molecular Design of a New Diboronic Acid for the Electrohydrodynamic Monitoring of Glucose

A new dicationic diboronic acid structure, DBA2+, was designed to exhibit good affinity (K_d ≈1 mm) and selectivity toward glucose. Binding of DBA2+ to glucose changes the pK_a of DBA2+ from 9.4 to 6.3, enabling opportunities for detection of glucose at physiological pH. Proton release from DBA2+ is firmly related to glucose concentrations within the physiologically relevant range (0-30 mm), as verified by conductimetric monitoring. Negligible interference from other sugars (for example, maltose, fructose, sucrose, lactose, and galactose) was observed. These results demonstrate the potential of DBA2+ for selective, quantitative glucose sensing. The nonenzymatic strategy based on electrohydrodynamic effects may enable the development of stable, accurate, and continuous glucose monitoring platforms.