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In Vitro Thrombosis Test for Ventricular Assist Devices
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Numerical modeling of continuous-flow left ventricular assist device performance
Dmitry Telyshev1,2, Dmitry Petukhov1, Sergey Selishchev1
1National Research University of Electronic Technology, Zelenograd, Russia.
The International Journal of Artificial Organs
|June 7, 2019
Summary
This study evaluated five rotary blood pumps using a cardiovascular model. Pump performance varied, with HeartMate II minimizing backflow and HeartWare offering maximal unloading, influenced by their unique pressure-flow curves.
Area of Science:
- Cardiovascular Engineering
- Biomedical Engineering
- Medical Device Analysis
Background:
- Rotary blood pumps are crucial for mechanical circulatory support.
- Understanding pump performance under various clinical conditions is essential.
- Mathematical modeling offers a robust method for evaluating device hemodynamics.
Purpose of the Study:
- To assess and compare the hemodynamic performance of five rotary blood pumps (HeartAssist 5, HeartMate II, HeartWare, Sputnik 1, Sputnik 2).
- To analyze pump responses across diverse clinical scenarios, including varying levels of ventricular support.
- To investigate the impact of pump pressure-flow characteristics on performance and adverse event likelihood.
Main Methods:
- Utilized a mathematical model of the cardiovascular system for simulation.
- Derived pump data from literature-reported pressure-flow curves.
- Evaluated pump responses across six distinct clinical test cases.
Main Results:
- HeartAssist 5, Sputnik 1, and Sputnik 2 exhibited similar aortic pressure and pulsatility.
- HeartMate II demonstrated minimal backflow due to a high pressure head at zero flow.
- HeartWare showed the least flow pulsation and greatest ventricular unloading, linked to a flat pressure-flow curve.
Conclusions:
- The shape of the pressure-flow curve significantly influences rotary blood pump performance.
- Higher pressure head at zero flow reduces backflow risk.
- Lower pressure head increases suction likelihood, highlighting the importance of pump selection based on clinical needs.
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