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Antibodies and vaccines against Middle East respiratory syndrome coronavirus

Jiuyang Xu1, Wenxu Jia1, Pengfei Wang2

  • 1a Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences , Tsinghua University School of Medicine , Beijing , People's Republic of China.

Emerging Microbes & Infections
|June 7, 2019
PubMed

Insights

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a global health threat. Research focuses on the MERS-CoV spike glycoprotein (S) for developing effective vaccines and therapeutics.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Middle East respiratory syndrome coronavirus (MERS-CoV) has caused over 2,200 infections and significant mortality since 2012.
  • No licensed vaccines or therapeutics are available, highlighting an urgent need for medical interventions.
  • The MERS-CoV spike glycoprotein (S) is crucial for viral entry and a key target for immune responses.

Purpose of the Study:

  • To review recent advancements in MERS-CoV therapeutics and vaccines targeting the S glycoprotein.
  • To discuss structural insights into MERS-CoV S protein-antibody interactions.
  • To identify challenges and strategies for translating MERS-CoV research into clinical applications.

Main Methods:

  • Literature review of studies on MERS-CoV monoclonal antibodies and vaccine candidates.
  • Analysis of structural data on MERS-CoV S protein-antibody complexes.
  • Discussion of current research trends and future directions in MERS-CoV intervention.

Main Results:

  • Development of monoclonal antibodies and candidate vaccines targeting the MERS-CoV S glycoprotein.
  • Structural studies reveal mechanisms of humoral immunity against MERS-CoV.
  • Progress in understanding MERS-CoV S protein interactions provides a basis for therapeutic development.

Conclusions:

  • The MERS-CoV S glycoprotein is a promising target for vaccine and therapeutic development.
  • Further research and structural studies are essential for overcoming hurdles in MERS-CoV intervention.
  • Translating current discoveries into effective medical countermeasures is critical for global public health.
Keywords:
CoronavirusMERS-CoVmonoclonal antibodyspike glycoproteinvaccine

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